The disposition of the narcotic antagonist/analgesic nalbuphine after i.v., oral, and rectal dosing was evaluated in rats and dogs. In both species nalbuphine had high systemic clearance and low oral bioavailability as a result of extensive first-pass metabolism. Administration to a closed 2 cm leng
Buccal and oral bioavailability of nalbuphine in rats
β Scribed by Munir A. Hussain; Bruce J. Aungst; Eli Shefter
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 156 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0022-3549
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