Brushed Block Copolymer Micelles with pH-Sensitive Pendant Groups for Controlled Drug Delivery
β Scribed by Lee, Hyun Jin; Bae, Younsoo
- Book ID
- 120553438
- Publisher
- Springer US
- Year
- 2013
- Tongue
- English
- Weight
- 508 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0724-8741
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## Abstract **Summary:** Novel pH sensitive biodegradable block copolymers (MPEGβPDLLAβOSM) composed of monoβmethoxy poly(ethylene glycol) (MPEG), poly (D,Lβlactide) (PDLLA) and sulfamethazine oligomer (OSM) were synthesized via ringβopening polymerization and a dicyclohexyl carboimide (DCC) coupli
Folate-conjugated unimolecular micelles based on amphiphilic hyperbranched block copolymer, Boltorn H40-poly(l-aspartate-doxorubicin)-b-poly(ethylene glycol)/FA-conjugated poly(ethylene glycol) (H40-P(LA-DOX)-b-PEG-OH/FA), were synthesized as a carrier for tumor-targeted drug delivery. The anticance