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Brownian dynamics simulation of nucleosome formation and disruption under stretching

โœ Scribed by Wei Li; Shuo-Xing Dou; Peng-Ye Wang

Book ID
104034434
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
626 KB
Volume
230
Category
Article
ISSN
0022-5193

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โœฆ Synopsis

Using a Brownian dynamics simulation, we numerically studied the interaction of DNA with histone and proposed an octamerrotation model to describe the process of nucleosome formation. Nucleosome disruption under stretching was also simulated. The theoretical curves of extension versus time as well as of force versus extension are consistent with previous experimental results.

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