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Bronchial hyperresponsiveness: insights into new signaling molecules

✍ Scribed by Yassine Amrani; Omar Tliba; Deepak A Deshpande; Timothy F Walseth; Mathur S Kannan; Reynold A Panettieri Jr

Book ID: 116383243
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 137 KB
Volume: 4
Category: Article
ISSN: 1471-4892
DOI: 10.1016/j.coph.2004.02.004

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## Abstract Chronic myelogenous leukemia (CML) is a myeloproliferative disease associated with a defined genetic abnormality, the Bcr‐Abl fusion gene on the Philadelphia chromosome that expresses the constitutively activated tyrosine kinase (TK) Bcr‐Abl. This enzyme leads to the malignant transform