## Abstract ## Background Though tobramycin inhalation solution has been used for over a decade to improve lung function and reduce exacerbations in patients with cystic fibrosis (CF), its effects on mortality have not been well‐described. This study aimed to assess the association between use of
Bronchial constriction after nebulized tobramycin preparations and saline in patients with cystic fibrosis
✍ Scribed by Wilfried H. Nikolaizik; Višnja Jenni-Galović; Martin H. Schöni
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 368 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0340-6997
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A recently developed tobramycin preparation for inhalation (TOBIா, Pathogenesis Corp., Seattle, WA) is widely used in CF patients. It is often used in conjunction with intravenous tobramycin. Renal and ototoxicity associated with the use of tobramycin require that serum drug concentrations be monito
To nine cystic fibrosis patients with chronic bronchopulmonary infection of severely damaged lungs invaded by Pseudomonas aeruginosa, eleven courses of prolonged tobramycin treatment (5 mg/kg/day) for four to 16 weeks were administered. Pulmonary symptoms improved and a better quality of life was ac
We have previously documented that ursodeoxycholic acid exerts a beneficial effect on liver function and bile acid metabolism in patients with cystic fi- brosis. We hypothesized that the mechanism of action may be related in part to the choleretic properties of the administered bile acid. We therefo