The structures of a dimeric and a tetrameric degraded dipeptide. derivable from bromotyrosine and cysteine, have been elucidated. Both compounds inhibit the growth of Bacillus subtiZis and Staphylococcus aLLI-eus. Bromotyrosine-derived secondary metabolites are characteristic of sponges of the order
Bromotyrosine-derived metabolites from the spongeAiolochroia crassa
β Scribed by Hongfeng Gao; Michelle Kelly; Mark T. Hamann
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 503 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
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β¦ Synopsis
A chemical investigation of secondary metabolites from the sponge Aiolochroia crassa has been performed and five bromotyrosine derivatives (1-5) were identified. Their structures have been assigned on the basis of spectroscopic analysis, of which araplysillin III (2) and hexadellin C (3) possess new structures. The absolute configurations of dibromotyrosine moieties of 2 were determined by HPLC analysis of derivatized constituent amino acids obtained from acid hydrolysis. The stereochemistry of the spirocyclohexadienylisoxazoline moiety of compounds 1-3 was deduced from spectroscopic comparison of the same moiety of aerothionin, of which the absolute configuration was previously assigned by X-ray and CD analysis. O 1999 Elsevier Science Ltd. All rights reserved.
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v