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Bromopyruvate as an active-site-directed inhibitor of the pyruvate dehydrogenase multienzyme complex from Escherichia coli

โœ Scribed by Lowe, Peter N.; Perham, Richard N.


Book ID
127263716
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
903 KB
Volume
23
Category
Article
ISSN
0006-2960

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The first enzymatic component, E1 (EC 1.2.4.1), of the pyruvate dehydrogenase multienzyme complex (PDHc) utilizes thiamine diphosphate (ThDP) and Mg(2+) as cofactors. The structure of a branched-chain-specific E1 apoenzyme from the heterotetrameric alpha(2)beta(2) E1 family was recently reported and