Bromodeoxyuridine inhibits the rDNA compensatory response ofDrosophila melanogaster

✍ Scribed by Krider, H. M. ;Levine, B. I.

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 460 KB
• Volume: 5
• Category: Article
• ISSN: 0192-253X
• DOI: 10.1002/dvg.1020050403

✦ Synopsis

The compensatory response is a regulatory event influencing the redundancy of the ribosomal RNA cistrons (rDNAs) of Drosophila melunogaster. In this report we attempt to demonstrate that the compensatory event and the thymidine analogue bromodeoxyuridine (BrdU) specifically interact. We conclude that the drug inhibits the compensatory response of Drosophila melunogaster XO males and argue that the compensatory event is not the passive consequence of replicational dominance known to occur in Drosophila polytene tissues.