Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor A1 allele
β Scribed by Lawford, Bruce R.; Young, Ross McD.; Rowell, John A.; Qualichefski, Joan; Fletcher, Barbara H.; Syndulko, Karl; Ritchie, Terry; Noble, Ernest P.
- Book ID
- 109928068
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 665 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1078-8956
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A total of 95 Caucasian opioid-dependent patients were followed over a one-year period in an outpatient methadone treatment program. The frequency of the TaqI A 1 allele of the D 2 dopamine receptor (DRD2) gene was 19.0% in these patients compared with 4.6% in controls free of past and current alcoh
To address the controversy surrounding DRDS and alcoholism, we performed linkage and association studies utilizing alcoholic men from high-density families largely uncontaminated by other psychopathology and female alcoholics for whom secondary drug dependence (averaging 10 years later onset) was a