Bromocriptine (CB-154) and the 8-alpha-ergoline CU 32-085, two dopamine receptor agonists, were administered at different times to two series of 22 patients with Parkinson's disease, most of whom took levodopa (plus benserazide) at optimum dosage. The addition of bromocriptine (mean daily dose 32 mg
β¦ LIBER β¦
BROMOCRIPTINE ASSOCIATED WITH A PERIPHERAL DOPAMINE BLOCKING AGENT IN TREATMENT OF PARKINSON'S DISEASE
β Scribed by Agid, Y.; Bonnet, A.M.; Pollak, P.; Signoret, J.L.; Lhermitte, F.
- Book ID
- 122066767
- Publisher
- The Lancet
- Year
- 1979
- Tongue
- English
- Weight
- 385 KB
- Volume
- 313
- Category
- Article
- ISSN
- 0140-6736
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## Abstract The presynaptic dopamine transporter in nigral dopaminergic neurons confers susceptibility to the cytotoxic effects of the neurotoxic metabolite of 1βmethy1β4βphenylβ1,2,3,6βtetrahydropyridine. Polymorphisms in the dopamine transporter might influence the susceptibility to such toxins.