Selective Bromination of 4,5-Dimethylthi
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Mouaffak Al Hariri; Olivier Galley; Félix Pautet; Houda Fillion
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Article
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1998
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John Wiley and Sons
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English
⚖ 313 KB
Radical bromination of 4,5-dimethylthiazole (1) was carried out using different stoichiometries of N-bromosuccinimide in the presence of 2,2Ј-azobisisobutyronitrile. Mono-, tri-and tetrabromo compounds 2, 5, and 6 were obtained in good yields with regioselectivity while the dibromo derivatives 3 and