Investigation of the genes for RET and i
Investigation of the genes for RET and its ligand complex, GDNF/GFRα-1, in small cell lung carcinoma
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Lois M. Mulligan; Tineke Timmer; Stacey M. Ivanchuk; Barbara G. Campling; Leah C
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Article
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1998
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John Wiley and Sons
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English
⚖ 82 KB
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RET is a receptor tyrosine kinase expressed in neuroendocrine cells and in tumors of these cell types. RET activation may be mediated by a ligand complex comprising glial cell line-derived neurotrophic factor (GDNF) and GDNF family receptor alpha-1 (GFR␣-1). Activating RET mutations are found in the