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BRIP1 (BACH1) variants and familial breast cancer risk: a case-control study

✍ Scribed by Bernd Frank; Kari Hemminki; Alfons Meindl; Barbara Wappenschmidt; Christian Sutter; Marion Kiechle; Peter Bugert; Rita K Schmutzler; Claus R Bartram; Barbara Burwinkel

Book ID
115011151
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
231 KB
Volume
7
Category
Article
ISSN
1471-2407

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Two potential breast cancer susceptibility genes, encoding the BRCA1-interacting proteins ZNF350 (or ZBRK1) and BRIP1 (or BACH1), have been identified in yeast two-hybrid screens. We sequenced these genes in probands from 21 families with potentially inherited breast/ovarian cancer, all of which wer