✦ LIBER ✦
Brief communication: Frequency of 47,+21 in cells of blood cultures from couples with habitual spontaneous abortion
✍ Scribed by Smith, Arabella ;Cohen, Margaret ;Murray, Robin
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 261 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
✦ Synopsis
Karyotyped specimens of peripheral blood from 1,055 chromosomally normal individuals (573 females, 482 males) presenting with habitual spontaneous abortion were examined for aneuploidy. Trisomy 21 was noted in six of 14,802 cells. These data were not significantly different from those obtained on chromosomes 19 and 20, or the data obtained from three different, smaller, control groups. The low rate of trisomy 21 cells found in this study suggests that we cannot extrapolate from events in somatic cells in mitosis to nondisjunction events in meiosis.