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Bridgehead Arylation: A Direct Route to Advanced Intermediates for the Synthesis of C-20 Diterpene Alkaloids

✍ Scribed by Williams, Craig M.; Mander, Lewis N.


Book ID
127285654
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
78 KB
Volume
5
Category
Article
ISSN
1523-7060

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A new route to the enantiomerically pure azetidin-2-one 3, a key intermediate for the synthesis of trinems, has been developed, incorporating enantioselective intramolecular C-H insertion of ct-methoxycarbonyl-ot-diazoacetamide catalyzed by chiral Rh(II) complexes and diastereoselective arene hydrog