Bridged Bicyclic Cores Containing a 1,1-Diarylethylene Motif Are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor

Synthesis of [3H]tert-butyl 8-chloro-5,6

Synthesis of [3H]tert-butyl 8-chloro-5,6-dihydro-5-methyl-6-oxo-4h-imidazo[1,5-a][1,4]benzodiazepine 3-carboxylate, a selective, high affinity ligand for the diazepam insensitive (DI) subtype of the benzodiazepine receptor

✍ Zi-Qiang Gu; Brian R. de Costa; Garry Wong; Kenner C. Rice; Phil Skolnick 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 388 KB 👁 1 views

## Abstract The preparation of [^3^H]‐labelled tert‐butyl 8‐chloro‐5,6‐dihydro‐5‐methyl‐6‐oxo‐4H‐imidazo[1,5‐a][1,4]benzodiazepine 3‐carboxylate (TCIB, 6), a high affinity ligands for the diazepam insensitive (DI) subtype of the benzodiazepine receptor (BZR) is described. Synthesis of [^3^H]TCIB wa