(+)-Brevione A. The first member of a novel family of bioactive spiroditerpenoids isolated from Penicillium brevicompactum Dierckx

✍ Scribed by Francisco A Macı́as; Rosa M Varela; Ana M Simonet; Horace G Cutler; Stephen J Cutler; Samir A Ross; D.Charles Dunbar; Frank M Dugan; Robert A Hill

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 120 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00223-9

✦ Synopsis

+)-Brevione A, the first member of a novel family of bioactive spiroditerpenoids, a potential allelopathic agent, has been isolated from the ethyl acetate active fractions of the aqueous acetone extracts of semi-solid fermented Penicillium brevicompactum Dierckx. The structure displays the novel spiroditerpenoid skeleton of breviane. The structure elucidation of brevione A was performed by homo-and hetero-nuclear 2D NMR spectral data. On the basis of combined studies of the theoretical conformations and NOEDIFF data, its relative stereochemistry is proposed.