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Brevenal Is a Natural Inhibitor of Brevetoxin Action in Sodium Channel Receptor Binding Assays

โœ Scribed by Andrea J. Bourdelais; Susan Campbell; Henry Jacocks; Jerome Naar; Jeffery L. C. Wright; Jigani Carsi; Daniel G. Baden


Book ID
111576719
Publisher
Springer
Year
2004
Tongue
English
Weight
366 KB
Volume
24
Category
Article
ISSN
0272-4340

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Brevetoxin PbTx-3 and non-toxic derivative 4 were investigated for their abilities to bind to the specific brevetoxin receptor site on rat brain synaptosomes and to modulate the normal function of voltage-gated sodium channels as determined by patch clamping of cultured neurons. Compounds 4 and 5 ar