Is the A-ring lactone of brevetoxin PbTX
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Professor Daniel G. Baden; Kathleen S. Rein; Robert E. Gawley; Gerhard Jeglitsch
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Article
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1994
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John Wiley and Sons
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English
โ 841 KB
Brevetoxin PbTx-3 and non-toxic derivative 4 were investigated for their abilities to bind to the specific brevetoxin receptor site on rat brain synaptosomes and to modulate the normal function of voltage-gated sodium channels as determined by patch clamping of cultured neurons. Compounds 4 and 5 ar