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Brefeldin A induces endoplasmic reticulum-associated O-glycosylation of galactosyltransferase

✍ Scribed by Herbert Bosshart; Peter Straehl; Bea Berger; Eric G. Berger

Book ID: 102885854
Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 830 KB
Volume: 147
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041470119

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✦ Synopsis

Recent data from several laboratories show that Brefeldin A (BFA) induces a microtubule-dependent back-flow of Golgi cornponents to the endoplasmic reticulum (ER) thereby causing disassembly of the Golgi apparatus and its fusion with ER membranes. In order to delineate the effect of BFA on resident Golgi proteins, we investigated its effect on biosynthesis, maturation and intracellular transport of galactosyltransferase (gal-T), an established trans-Golgi enzyme.

Using a protocol of metabolic labeling'immunoprecipitation followed bv electrophoreticifluorographic analysis, we show that in the presence of BFA, gal-T matures to a molecular form of 48.5 kD, a size intermediate between the 2 precursor forms of 44 and 47 and the mature form of 54 kD (Strous and Berger:

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