Breast Pathology (Consultant Pathology Volume 6)

✍ Scribed by Melinda Sanders, Jean Simpson, David Elder

• Publisher: Demos Medical / Springer Publishing Company
• Year: 2014
• Tongue: English
• Leaves: 324
• Series: Consultant Pathology
• Edition: 1st
• Category: Library

✦ Synopsis

Based on actual cases drawn from the extensive breast pathology consultation practice at Vanderbilt University Medical Center, Breast Pathology covers the full classification of breast tumors and focuses on especially challenging differential diagnoses or unusual and problematic morphologic presentations. Using a pattern-based approach, each case is presented as a difficult diagnostic choice with two or even three possible diagnoses for the pathologist. For each case there is a description illustrating an expert's diagnosis and analysis, along with commentary providing additional context on the evaluation of such specimens. The book places special emphasis on avoiding diagnostic pitfalls. Each case discussion is supported with several high quality color photomicrographs that facilitate an extensive visual history and learning experience. Brief references to the literature are also included.

The book presents a foreword by David L. Page, MD, Professor of Pathology, Vanderbilt University Medical Center.

Key Features of Breast Pathology:

Provides a pattern-based approach to solving difficult diagnostic challenges
Offers expert guidance to complex diagnoses of breast specimens
Emphasizes difficult diagnoses and how to avoid diagnostic pitfalls
Based on actual cases drawn from breast pathology consultation practice at Vanderbilt University Medical Center
Includes over 400 high quality color photomicrographs

✦ Table of Contents

Cover......Page 1
Title......Page 4
Copyright......Page 5
Contents......Page 8
Series Foreword......Page 12
Foreword......Page 14
Preface......Page 16
Chapter 1: Alterations of Enlarged Lobular Units......Page 18
1.1 Enlarged Lobular Unit With Apocrine Change......Page 21
Case 2......Page 23
1.3 Columnar Cell Lesions With Atypia......Page 26
1.4 Secretory Change......Page 28
Chapter 2: Epithelial Proliferative Lesions......Page 30
2.1 Hyperplasia Without Atypia, Usual and Florid Patterns......Page 35
Case 1......Page 37
Case 2......Page 38
2.3 Usual Hyperplasia Without Atypia, Compact Pattern......Page 40
Case 1......Page 42
Case 2......Page 43
2.5 Usual Hyperplasia With Prominent Myoepithelial Cells......Page 45
2.6 Usual Hyperplasia With Clear Cells......Page 47
Case 2......Page 49
Case 1......Page 52
Case 2......Page 53
2.9 Atypical Ductal Hyperplasia, Solid Pattern......Page 56
2.10 Atypical Ductal Hyperplasia, Micropapillary Pattern......Page 58
2.11 Atypical Ductal Hyperplasia With Apocrine Cytology......Page 60
2.12 Hypersecretory Hyperplasia......Page 62
2.13 Atypical Ductal Hyperplasia in a Background of Hypersecretory Hyperplasia......Page 64
2.14 Florid Hyperplasia Involving a Papilloma......Page 66
2.15 Cells of Atypical Lobular Hyperplasia Admixed With Florid Hyperplasia, Involving an Intraductal Papilloma......Page 68
2.16 Collagenous Spherulosis Involving Micropapillomas......Page 70
2.17 Papilloma Involved by Atypical Ductal Hyperplasia......Page 72
2.18 Nipple Adenoma......Page 74
2.19 Mucocele-Like Lesion......Page 76
2.20 Mucocele-Like Lesion With Atypical Ductal Hyperplasia......Page 78
Chapter 3: Ductal Carcinoma In Situ, Special Considerations......Page 80
3.1 Ductal Carcinoma In Situ, Low Grade, Minimal Example......Page 87
3.2 Ductal Carcinoma In Situ, Solid Pattern Mimicking Lcis......Page 89
Case 2......Page 91
3.4 Spindle Cell Pattern Ductal Carcinoma......Page 94
3.5 Ductal Carcinoma In Situ With Florid-Like Pattern......Page 96
3.6 Ductal Carcinoma In Situ With Biphasic Pattern......Page 98
Case 1......Page 100
Case 2......Page 101
Case 3......Page 103
3.8 Micropapillary Ductal Carcinoma In Situ......Page 105
3.9 Ductal Carcinoma In Situ Arising in a Background of Hypersecretory Hyperplasia......Page 107
Case 1......Page 109
Case 2......Page 110
Case 1......Page 113
Case 2......Page 114
3.12 Invasive Carcinoma Associated With Ductal Carcinoma In Situ......Page 116
3.13 Encysted Noninvasive Papillary Carcinoma......Page 118
3.14 Ductal Carcinoma In Situ Involving a Papilloma With Areas of Pseudoinvasion......Page 120
3.15 Paget’s Disease of the Nipple......Page 123
3.16 Toker Cells......Page 125
3.17 Ductal Carcinoma In Situ With Tall Cell Pattern, Involving Papillomas......Page 126
3.18 Secretory Ductal Carcinoma In Situ......Page 128
3.19 Pagetoid Pattern Ductal Carcinoma In Situ......Page 130
3.20 Radiation Change Mimicking Ductal Carcinoma In Situ......Page 132
Chapter 4: Lobular Neoplasia......Page 134
Case 1......Page 138
Case 2......Page 139
4.2 Classic Lobular Carcinoma In Situ......Page 141
4.3 Lobular Carcinoma In Situ Involving a Fibroadenoma and an Adjacent Lobular Unit......Page 143
Chapter 5: Sclerosing and Adenotic Lesions......Page 146
5.1 Nodular Apocrine Sclerosing Adenosis......Page 150
Case 1......Page 152
Case 2......Page 153
5.3 Adenomyoepithelioma......Page 156
5.4 Radial Scar......Page 159
5.5 Atypical Lobular Hyperplasia Involving Sclerosing Adenosis Associated With a Radial Scar......Page 161
5.6 Microglandular Adenosis......Page 164
5.7 Atypical Microglandular Adenosis......Page 166
Chapter 6: Fibroepithelial Lesions......Page 168
6.1 Cellular Fibroadenoma......Page 172
6.2 Atypical Ductal Hyperplasia Involving a Fibroadenoma......Page 174
6.3 Atypical Lobular Hyperplasia Involving a Fibroadenoma......Page 176
Case 1......Page 178
Case 2......Page 179
Case 2......Page 181
Case 1......Page 184
Case 2......Page 186
Case 3......Page 187
6.7 Hamartoma......Page 190
Chapter 7: Reactive and Benign Stromal Lesions......Page 192
7.1 Pseudoangiomatous Stromal Hyperplasia......Page 196
7.2 Reactive Spindle Cell Nodule......Page 198
7.3 Nodular Fasciitis......Page 201
7.4 Cellular Myofibroblastoma......Page 204
7.5 Epithelioid Myofibroblastoma......Page 206
7.6 Fibromatosis......Page 209
7.7 Sclerosing Lymphocytic Lobulitis......Page 212
Chapter 8: Special Type Carcinomas......Page 214
Case 1......Page 221
Case 2......Page 222
Case 3......Page 223
Case 1......Page 225
Case 2......Page 226
Case 1......Page 229
Case 2......Page 230
Case 1......Page 232
Case 2......Page 233
Case 3......Page 234
Case 4......Page 235
Case 5......Page 236
Case 6......Page 237
8.5 Secretory Carcinoma......Page 239
Case 1......Page 241
Case 2......Page 243
Case 1......Page 246
Case 2......Page 247
8.8 Low Grade Adenosquamous Carcinoma......Page 250
Chapter 9: Invasive Carcinomas, Special Considerations......Page 252
9.1 Invasive Micropapillary Features......Page 256
9.2 Retraction Artifact......Page 258
9.3 Invasive Carcinoma With Apocrine Differentiation......Page 260
9.4 Invasive Carcinoma With Medullary Features......Page 262
Case 1......Page 264
Case 2......Page 265
Case 3......Page 266
9.6 Solid Pattern Invasive Carcinoma Mimicking Ductal Carcinoma In Situ......Page 268
9.7 Lymphovascular Invasion Mimicking Ductal Carcinoma In Situ......Page 270
9.8 Invasive Mammary Carcinoma in a Background of Microglandular Adenosis......Page 272
9.9 Entrapped Squamous Morules Within a Previous Biopsy Site Reaction......Page 274
Chapter 10: Sentinel Lymph Nodes......Page 276
10.1 Benign Transport......Page 280
10.2 Isolated Tumor Cell Clusters......Page 282
10.3 Micrometastasis......Page 284
10.4 Capsular Lymphatic Involvement......Page 286
10.5 Benign Glandular Inclusion......Page 288
10.6 Metastatic Lobular Carcinoma......Page 290
Chapter 11: The Male Breast......Page 292
Case 1......Page 295
Case 2......Page 296
11.2 Atypical Ductal Hyperplasia Arising in the Setting of Gynecomastia......Page 298
11.3 Ductal Carcinoma In Situ......Page 300
Case 1......Page 302
Case 2......Page 303
Chapter 12: Vascular Lesions of the Breast......Page 306
12.1 Perilobular Capillary Hemangioma......Page 309
12.2 Angiolipoma......Page 310
12.3 Atypical Vascular Lesion......Page 312
Case 2......Page 314
12.5 Epithelioid Angiosarcoma......Page 317
Index......Page 320

✦ Subjects

Pathology; Anatomic Pathology; Breast Pathology