𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

✍ Scribed by Anne-Renee Hartman; Bruce L. Daniel; Allison W. Kurian; Meredith A. Mills; Kent W. Nowels; Frederick M. Dirbas; Kerry E. Kingham; Nicki M. Chun; Robert J. Herfkens; James M. Ford; Sylvia K. Plevritis

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
205 KB
Volume
100
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

BACKGROUND

Intensive screening is an alternative to prophylactic mastectomy in women at high risk for developing breast carcinoma. The current article reports preliminary results from a screening protocol using high‐quality magnetic resonance imaging (MRI), ductal lavage (DL), clinical breast examination, and mammography to identify early malignancy and high‐risk lesions in women at increased genetic risk of breast carcinoma.

METHODS

Women with inherited BRCA1 or BRCA2 mutations or women with a > 10% risk of developing breast carcinoma at 10 years, as estimated by the Claus model, were eligible. Patients were accrued from September 2001 to May 2003. Enrolled patients underwent biannual clinical breast examinations and annual mammography, breast MRI, and DL.

RESULTS

Forty‐one women underwent an initial screen. Fifteen of 41 enrolled women (36.6%) either had undergone previous bilateral oophorectomy and/or were on tamoxifen at the time of the initial screen. One patient who was a BRCA1 carrier had high‐grade ductal carcinoma in situ (DCIS) that was screen detected by MRI but that was missed on mammography. High‐risk lesions that were screen detected by MRI in three women included radial scars and atypical lobular hyperplasia. DL detected seven women with cellular atypia, including one woman who had a normal MRI and mammogram.

CONCLUSIONS

Breast MRI identified high‐grade DCIS and high‐risk lesions that were missed by mammography. DL detected cytologic atypia in a high‐risk cohort. A larger screening trial is needed to determine which subgroups of high‐risk women will benefit and whether the identification of malignant and high‐risk lesions at an early stage will impact breast carcinoma incidence and mortality. Cancer 2004. © 2004 American Cancer Society.

📜 SIMILAR VOLUMES

Screening women at high risk for breast
Screening women at high risk for breast cancer with mammography and magnetic resonance imaging
✍ Constance D. Lehman; Jeffrey D. Blume; Paul Weatherall; David Thickman; Nola Hyl 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 112 KB 👁 1 views

## Abstract ## BACKGROUND The authors compared the performance of screening mammography versus magnetic resonance imaging (MRI) in women at genetically high risk for breast cancer. ## METHODS The authors conducted an international prospective study of screening mammography and MRI in asymptomati

Probably benign lesions at breast magnet
Probably benign lesions at breast magnetic resonance imaging : Preliminary experience in high-risk women
✍ Laura Liberman; Elizabeth A. Morris; Catherine L. Benton; Andrea F. Abramson; D. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 252 KB 👁 1 views

## Abstract ## BACKGROUND The purpose of the current study was to determine the frequency of ‘probably benign’ interpretations at breast magnetic resonance (MR) imaging screening of high‐risk women and the frequency of subsequent malignancy in these women. ## METHODS The authors performed a retr

Effectiveness of alternating mammography
Effectiveness of alternating mammography and magnetic resonance imaging for screening women with deleterious BRCA mutations at high risk of breast cancer
✍ Huong T. Le-Petross; Gary J. Whitman; Deanne P. Atchley; Ying Yuan; Angelica Gut 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 318 KB 👁 1 views

## Abstract ## BACKGROUND: Magnetic resonance imaging (MRI) has been used to supplement screening mammography and clinical breast examination (CBE) in women who are at high risk of developing breast cancer. In this study, the authors investigated the efficacy of alternating screening mammography a