Breast carcinoma after cancer therapy in childhood

✍ Scribed by Frederick P. Li; Joseph Corkery; Gordon Vawter; William Fine; Stephen E. Sallan

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 283 KB
• Volume: 51
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19830201)51:3<521::aid-cncr2820510325>3.0.co;2-u

✦ Synopsis

Among 910 survivors of childhood cancer, four developed infiltrating carcinoma of the breast and another had noninfiltrating breast tumor. Expected frequency was 0.3 cases of breast cancer in the series. The affected women developed breast carcinoma at ages 20, 25 and 38 years, and the men at ages 38 and 39 years, respectively. Each patient had received orthovoltage chest irradiation for treatment of Wilms' tumor or bone sarcoma between seven and 34 years previously, and estimated radiation dose to the breast exceeded 300 rad in each instance. Four patients also received diverse forms of chemotherapy. Survivors of childhood cancer have increased risk of developing breast cancer and should undergo periodic screening, particularly after breast tissue had been irradiated. Individualized radiotherapy planning can help exclude the breasts from treatment fields for some thoracic neoplasms.

Cancer 5 1 5 2 1 4 2 3 , 1983.

ECENT STUDIES show an increased risk of breast R cancer in women exposed to chest radiation in early adulthood. ' Data are scanty on the carcinogenic effects of irradiation at older ages and in childhood. This report examines the development of breast cancer in a cohort of patients who had received radiotherapy and other treatments for neoplasia in childhood.