Breast cancer risks in individuals testing negative for a known family mutation inBRCA1orBRCA2
β Scribed by S. M. Domchek; M. M. Gaudet; J. E. Stopfer; M. H. Fleischaut; J. Powers; N. Kauff; K. Offit; K. L. Nathanson; M. Robson
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 170 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
About 5-10% of breast cancer cases are hereditary and attributable to mutations in several susceptibility genes from which to date only 2 have been identified: BRCA1 (17q21) and BRCA2 (13q12). However, the BRCA genes only explain about 30% of familial breast/ovarian cancer, suggesting the existence
## BACKGROUND. Two genes responsible for hereditary breast cancer (BRCA1 and BRCA2) have been identified, and predisposing mutations identified. Several studies have provided evidence that germline mutations in BRCA1 and BRCA2 confer an increased risk of prostate cancer. Based on these findings, o