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Breaking the left–right axis: do nodal parcels pass a signal to the left?

✍ Scribed by Dominic Norris

Book ID
101707876
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
89 KB
Volume
27
Category
Article
ISSN
0265-9247

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✦ Synopsis

In mammals, left-right symmetry is broken by a mechanically driven leftward flow of liquid at the embryonic node (nodal flow). Various models have emerged explaining how this may happen. Work from Tanaka and colleagues (1) has provided a new mechanism by which nodal flow may be breaking symmetry. They describe small membrane-bound particles, which they term nodal vesicular parcels (NVPs), that are carried to the left side of the node. In the paper, they argue how signals carried within these parcels may break L-R symmetry. BioEssays 27: 991-994, 2005.

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## Abstract Nodal factors play crucial roles during embryogenesis of chordates. They have been implicated in a number of developmental processes, including mesoderm and endoderm formation and patterning of the embryo along the anterior–posterior and left–right axes. We have analyzed the function of