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Breaking the adhesions of a cell with its substratum

✍ Scribed by Kaetrin Simpson; Michael McGrath; Adam Curtis

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
613 KB
Volume
17
Category
Article
ISSN
1065-6995

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✦ Synopsis

Abstract

Investigation of the relative slowness with which trypsin detaches epithelial cells from their adhesions with a substratum suggests that the adherent surface of the cells is normally rather inaccessible to the enzyme. Trypsinisation of cells through a porous filter allowing access of the enzyme to the underside of the cells greatly accelerated detachment: a result consistent with this explanation.

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