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Breaking non-native hydrophobic clusters is the rate-limiting step in the folding of an alanine-based peptide

✍ Scribed by Shibasish Chowdhury; Wei Zhang; Chun Wu; Guoming Xiong; Yong Duan

Book ID
101718338
Publisher
Wiley (John Wiley & Sons)
Year
2002
Tongue
English
Weight
470 KB
Volume
68
Category
Article
ISSN
0006-3525

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πŸ“œ SIMILAR VOLUMES

The rate-limiting step in the folding of
The rate-limiting step in the folding of the cis-Pro167Thr mutant of TEM-1 Ξ²-lactamase is the trans to cis isomerization of a non-proline peptide bond
✍ Marc Vanhove; Xavier Raquet; Timothy Palzkill; Roger H. Pain; Jean-Marie FrΓ¨re πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 746 KB

The stability and kinetics of unfolding and refolding of the P167T mutant of the TEM-1 p-lactamase have been investigated as a function of guanidine hydrochloride concentration. The activity of the mutant enzyme was not significantly modified, which strongly suggests that the Glu166Thr167 peptide bo