Breakdown of prothrombin and proconvertin in rats with experimental extrahepatic cholestasis
β Scribed by V. I. Kiyanov
- Publisher
- Springer US
- Year
- 1974
- Tongue
- English
- Weight
- 159 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0007-4888
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## Abstract The longβterm (5βweek) evolution of two experimental models of extrahepatic cholestasis, i.e., macrosurgical by bile duct ligation (n = 20) and microsurgical by biliary tract resection (n = 13), is studied. All cholestatic animals showed jaundice, choluria, and portosystemic collateral
Dawley rats (obtained from the Su Β¨ddeutsche Versuchstierfarm, Tutand J.R. (32-30168.90), and by a grant from the Department of Clinical Research of the tlingen, Germany) were used for all experiments. Rats had free ac-University of Berne to L.K. cess to drinking water and regular rat diet (Kliba Fu
The biliary excretion and apparent oral clearance of metoclopramide (MCL) were determined after oral administration of 1 mg MCL/kg body weight to 10 patients suffering from extrahepatic cholestasis with nasobiliary tube for drainage of the common bile duct. A bilioduodenal endoprosthesis was subsequ