Breakage–fusion–bridge cycles leading to
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Thierry Voet; Evelyne Vanneste; Niels Van der Aa; Cindy Melotte; Sigrun Jackmaer
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Article
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2011
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John Wiley and Sons
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English
⚖ 633 KB
Recently, a high incidence of chromosome instability (CIN) was reported in human cleavage stage embryos. Based on the copy number changes that were observed in the blastomeres it was hypothesized that chromosome breakages and fusions occur frequently in cleavage stage human embryos and instigate sub