BRCA2 mutation screening is clinically relevant in breast and early prostate cancer families
✍ Scribed by Abdel-Rahene Azzouzi; Dominique Stoppa-Lyonnet; Morgan Roupret; Stéphane Larre; Philippe Mangin; Oliver Cussenot
- Book ID
- 108977341
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 83 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0919-8172
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We have screened index cases from 25 Russian breast/ovarian cancer families for germ-line mutations in all coding exons of the BRCA1 and BRCA2 genes, using multiplex heteroduplex analysis. In addition we tested 22 patients with breast cancer diagnosed before age 40 without family history and 6 patie
The entire coding regions of BRCA1 and BRCA2 were screened for mutations by heteroduplex analysis in 51 Mexican breast cancer patients. One BRCA1 and one BRCA2 truncating mutation each was identified in the group of 32 (6%) early-onset breast cancer patients (< or =35 years). Besides these two likel