In a recent article, Frolov et al. (2002) stated that only five somatic mutations in BRCA1 have been identified in sporadic ovarian carcinomas (Hosking et al., 1995;Merajver et al., 1995) and that only one case of clear cell carcinoma had been reported to be associated with BRCA1 mutations (Hartley
BRCA1mutation update and analysis
β Scribed by Klaus Grade; Burkhard Jandrig; Siegfried Scherneck
- Book ID
- 112498049
- Publisher
- Springer-Verlag
- Year
- 1996
- Tongue
- English
- Weight
- 419 KB
- Volume
- 122
- Category
- Article
- ISSN
- 1432-1335
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Since the isolation of BRCA1, the familial breast/ovarian cancer predisposition gene, much effort has been invested in characterizing the mutation spectrum. The large size of the gene and the wide distribution of its more than 100 mutations has increased the challenge of this endeavor such that trad
Sixty high-risk breast and/or ovarian cancer families from North-Eastern Poland were screened for germline mutations in BRCA1 (MIM# 113705) and BRCA2 (MIM# 600185), using a combination of protein truncation test, denaturing high-performance liquid chromatography and direct sequencing. Sixteen (27%)