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BRCA1/BRCA2gene mutations/SNPs andBRCA1haplotypes in early-onset breast cancer patients of Indian ethnicity

โœ Scribed by Abida Juwle, Dhananjaya Saranath


Book ID
118821680
Publisher
Springer US
Year
2012
Tongue
English
Weight
295 KB
Volume
29
Category
Article
ISSN
1357-0560

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Mutations in the familial early-onset breast cancer gene (BRCA1) account for approximately 2-5% of all breast cancer cases (Easton et al., 1993). Since the isolation of the BRCA1 gene in 1994, many mutations have been identified. We report here a total of 254 BRCA1 mutations, 132 (52%) of which are