Brca1 required for T cell lineage development but not TCR loci rearrangement
β Scribed by Hakem, Razqallah; Mak, Tak W.; Hakem, Anne; McPherson, J. Peter; Shehabeldin, Amro; Zablocki, Elzbieta; Migon, Eva; Duncan, Gordon S.; Bouchard, Denis; Wakeham, Andrew; Cheung, Alison; Karaskova, Jana; Sarosi, Ildiko; Squire, Jeremy; Marth, Jamey
- Book ID
- 109828449
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 403 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1529-2908
- DOI
- 10.1038/76950
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Most natural killer T (NKT) cells express a highly skewed Β§ g TCR repertoire, consisting of an invariant V Β§ 14-J Β§ 281 chain paired preferentially with a polyclonal V g 8.2 chain. This repertoire is positively selected by the monomorphic CD1d molecule expressed on cells of hematopoietic origin. The
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