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BRCA1 mutations in African Americans

โœ Scribed by R.C.K. Panguluri; L.C. Brody; R. Modali; K. Utley; L. Adams-Campbell; A.A. Day; C. Whitfield-Broome; G.M. Dunston

Publisher
Springer
Year
1999
Tongue
English
Weight
71 KB
Volume
105
Category
Article
ISSN
0340-6717

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Germline mutations in the BRCA1 (MIM 113705) and BRCA2 (MIM 600185) genes have been identified for breast and ovarian cancer families of diverse ethnic backgrounds. To date, there have been no reports of Native North American families with mutations in BRCA1 or BRCA2. Here we report two families of

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In a recent article, Frolov et al. (2002) stated that only five somatic mutations in BRCA1 have been identified in sporadic ovarian carcinomas (Hosking et al., 1995;Merajver et al., 1995) and that only one case of clear cell carcinoma had been reported to be associated with BRCA1 mutations (Hartley