𝔖 Bobbio Scriptorium
✦   LIBER   ✦

BRCA1 in the family: A case description of the psychological implications

✍ Scribed by DudokdeWit, A. C.; Tibben, A.; Frets, P. G.; Meijers-Heijboer, E. J.; Devilee, P.; Klijn, J. G. M.; Oosterwijk, J. C.; Niermeijer, M. F.

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
21 KB
Volume
71
Category
Article
ISSN
0148-7299

No coin nor oath required. For personal study only.

✦ Synopsis

Our experience with the first family in the Netherlands for whom predictive DNAtesting for Hereditary Breast and Ovarian Cancer (HBOC) became an option is described. This serves to illustrate the complex emotional impact on a family as a whole, and upon the members separately, of becoming aware that breast and ovarian cancer is hereditary, and the implications of undergoing predictive testing. All family members received genetic counseling and were offered pre-and post-test psychological follow-up.

We observed two important roles within the family. One member became ''the messenger of the news'' informing the relatives of the hereditary character of cancer in the family. Another was ''the first utilizer'' of the new options; namely, the predictive DNAtest and preventive surgery. This first utilizer became the example to the rest of the family. Decisions made about preventive treatment (prophylactic ovariectomy and/or mastectomy) were based on the experiences within the family, whether one identified with an affected family member with breast or with ovarian cancer.

The actions and reactions perceived were illustrative of what kind of support provisions should be provided in addition to the genetic and oncological counseling for HBOC. Moreover HBOC should be considered both as an individual and a family problem and be treated as such in genetic counseling. Am. J. Med. Genet. 71:63-71, 1997.

πŸ“œ SIMILAR VOLUMES

Implications of a novel cryptic splice s
Implications of a novel cryptic splice site in the BRCA1 gene
✍ Hoffman, Jodi D.; Hallam, Stephanie E.; Venne, Vickie L.; Lyon, Elaine; Ward, Ke πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 25 KB πŸ‘ 1 views

This study was designed to determine the significance of a single intronic base change (IVS5 -12 G→A) found in a family with a history of breast cancer. This change is predicted to form a cryptic splice site resulting in the addition of 11 nucleotides to the BRCA1 transcript. The BRCA1 gene of the r

The description of gay and lesbian famil
The description of gay and lesbian families in second-parent adoption cases
✍ Catherine Connolly πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 183 KB

Lesbians and gay men are turning to the courts to recognize their family relationships. In this article every reported court decision where a lesbian or gay couple has successfully completed a second-parent adoption is reviewed to analyze the presentation and judicial analysis of the petitioning par

A novel mutation in the BRCA1 gene in a
A novel mutation in the BRCA1 gene in a German early-onset breast cancer family
✍ Beate Waindzoch; Klaus Grade; Burkhard Jandrig; Manuela MΓΌller; Peter Schlag; Si πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 117 KB πŸ‘ 2 views

severe pulmonary and intestinal disease including ileus at birth and liver cirrhosis at the age 5 years, whereas the other one developed much better with only mild pulmonary changes. Clinical follow-up evaluation of our patient, a 5-year-old girl, was evocative of an intermediary status. Diagnosis o