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BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair

✍ Scribed by Samuel F. Bunting; Elsa Callén; Marina L. Kozak; Jung Min Kim; Nancy Wong; Andrés J. López-Contreras; Thomas Ludwig; Richard Baer; Robert B. Faryabi; Amy Malhowski; Hua-Tang Chen; Oscar Fernandez-Capetillo; Alan D'Andrea; André Nussenzweig

Book ID
116755164
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
895 KB
Volume
46
Category
Article
ISSN
1097-2765

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## Abstract The role of the region encoded by exon 27 of the __Brca2__ gene in DNA repair was studied in cells and tissues from __Brca2^Δ27/Δ27^__ mice. The COOH‐terminal truncated Brca2 localized to the nucleus in primary mouse embryo fibroblasts from __Brca2^Δ27/Δ27^__ mice. Fluorescence‐activate