BRCA1 and its phosphorylation involved in caffeine-inhibitable event upstream of G2 checkpoint

Checkpoint kinase 1-mediated phosphoryla

Checkpoint kinase 1-mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine-induced G2/M phase cell-cycle arrest and apoptosis

✍ Jinn-Shiun Chen; Shyr-Yi Lin; Wei-Ling Tso; Geng-Chang Yeh; Wen-Sen Lee; How Tse 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 678 KB

## Abstract In this study, we first demonstrated that loratadine (LOR), a promising world widely used oral anti‐histamine, effectively inhibits growth of tumors derived from human colon cancer cells (COLO 205) in an in vivo setting. In vitro study demonstrated that the anti‐tumor effects of LOR in