BRCA1 and BRCA2 analysis in breast cancer families from Sardinia: identification of two BRCA2 founder mutations with their clinical and pathological implications
β Scribed by M. Pisano; G. Palomba; A. Cossu; G. Palmieri; M. Ibba; M. Sarobba; M. Dedola; M. Satta; M. Pirastu; F. Tanda
- Book ID
- 117658497
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 164 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0959-8049
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Germline mutations in the BRCA1 and BRCA2 genes account for the majority of high-risk breast/ovarian cancer families, depending on the population studied. Previously, BRCA1 mutations were described in women from Western Poland. To further characterize the spectrum of BRCA1 mutations and the impact o
Sixty high-risk breast and/or ovarian cancer families from North-Eastern Poland were screened for germline mutations in BRCA1 (MIM# 113705) and BRCA2 (MIM# 600185), using a combination of protein truncation test, denaturing high-performance liquid chromatography and direct sequencing. Sixteen (27%)
Reports on the prognosis of familial breast cancer patients have been contradictory. True differences in survival, if they exist, would have important implications for genetic counselling and in treatment of hereditary breast cancer. We assessed the survival rates of 359 familial breast cancer patie