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BRCA1 and BRCA2: 1994 and beyond

✍ Scribed by Narod, Steven A.; Foulkes, William D.

Book ID
109947234
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
230 KB
Volume
4
Category
Article
ISSN
1474-1776

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## RESULTS. BRCA1 is an estrogen-inducable cell cycle-associated protein with antiproliferation and tumor suppressor function. Less is known about BRCA2 protein 1 Department of Pathology, St. Luke's Hospital, but it has some similarities to BRCA1. Release of cells from BRCA1 control through Chester

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## Abstract The subcellular location and function of many proteins are regulated by nuclear–cytoplasmic shuttling. BRCA1 and BARD1 provide an interesting model system for understanding the influence of protein dimerization on nuclear transport and localization. These proteins function predominantly