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Brainstem 1H nuclear magnetic resonance (NMR) spectroscopy: Marker of demyelination and repair in spinal cord

✍ Scribed by Aleksandar Denic; Allan Bieber; Arthur Warrington; Prasanna K. Mishra; Slobodan Macura; Moses Rodriguez

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
332 KB
Volume
66
Category
Article
ISSN
0364-5134

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✦ Synopsis

Abstract

Measuring in vivo spinal cord injury and repair remains elusive. Using magnetic resonance spectroscopy (MRS) we examined brainstem N‐acetyl‐aspartate (NAA) as a surrogate for spinal cord injury in two mouse strains with different reparative phenotypes following virus‐induced demyelination. Swiss Jim Lambert (SJL) and Friend Virus B (FVB) mice progressively demyelinate with axonal loss. FVB mice demyelinate similarly but eventually remyelinate coincident with functional recovery. Brainstem NAA levels drop in both but recover in FVB mice. Chronically infected SJL mice lost 30.5% of spinal cord axons compared to FVB mice (7.3%). In remyelination‐enhancing or axon‐preserving clinical trials, brainstem MRS may be a viable endpoint to represent overall spinal cord dysfunction. Ann Neurol 2009;66:559–564

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