𝔖 Bobbio Scriptorium
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Brain uptake of labelled adiphenine in rats

✍ Scribed by J. Michelot; M. F. Moreau; A. Veyre; P. Labarre; G. Meyniel

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
432 KB
Volume
7
Category
Article
ISSN
0142-2782

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✦ Synopsis

This study describes the behaviour of a dual labelled drug, adiphenine, in the rat brain. Macroautoradiographies show images of the brain at different times after injection. Some of the tissue metabolites are identified at the brain level and the passage of the blood brain barrier is compared with tritiated water.

The obtained data give very interesting indications on the blood brain distribution and on the metabolism at the brain level. Different techniques of high pressure liquid chromatography, macro-and histoautoradiographies allowed us to visualize how the drug is fixed on cerebral structures, giving indications on its mechanism of action.

This fat soluble compound freely crosses the normal blood brain barrier and if labelled with the appropriate emittor could be very useful in nuclear medicine to obtain imaging of the brain.

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