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Brain tumor therapy by combined vaccination and antisense oligonucleotide delivery with nanoparticles

โœ Scribed by Thomas Schneider; Andreas Becker; Kerstin Ringe; Annegret Reinhold; Raimund Firsching; Bernhard A. Sabel


Book ID
113730224
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
524 KB
Volume
195
Category
Article
ISSN
0165-5728

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We have reported that antisense Bcl-2 oligodeoxynucleotide (ODN) delays progression to androgen independence in the androgen-dependent (AD) mouse Shionogi tumor model. Here, we characterize changes in bcl-xL, another important anti-apoptotic gene, and test the efficacy of adjuvant antisense Bcl-xL O