Brain tumor chemotherapy with intrathecal methotrexate
β Scribed by Charles B. Wilson; Horace A. Norrell Jr.
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 735 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0008-543X
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In the treatment of patients with meningeal leukemia, conventional intrathecal methotrexate therapy followed by maintenance intrathecal methotrexate at intervals of 8 weeks has been shown superior to an intensive, unmaintained intrathecal methotrexate induction regimen, and to neuroaxis radiotherapy
## Abstract Twentyβthree children with CNS tumors were treated with combination chemotherapy including nitrogen mustard, vincristine sulfate, procarbazine, and prednisone (MOPP). All but one had progressive or recurrent tumors following surgery and irradiation. In addition, nine of these patients h