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Brain progranulin expression inGRN-associated frontotemporal lobar degeneration

✍ Scribed by Alice S. Chen-Plotkin; Jiping Xiao; Felix Geser; Maria Martinez-Lage; Murray Grossman; Travis Unger; Elisabeth M. Wood; Vivianna M. Van Deerlin; John Q. Trojanowski; Virginia M.-Y. Lee

Publisher
Springer-Verlag
Year
2009
Tongue
English
Weight
472 KB
Volume
119
Category
Article
ISSN
0001-6322

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## Communicated by Mark H. Paalman Mutations in the gene encoding granulin (HUGO gene symbol GRN, also referred to as progranulin, PGRN), located at chromosome 17q21, were recently linked to tau-negative ubiquitin-positive frontotemporal lobar degeneration (FTLDU). Since then, 63 heterozygous muta