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Brain polyamine levels are altered in Alzheimer's disease

โœ Scribed by Lesley D. Morrison; Stephen J. Kish


Book ID
116124961
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
320 KB
Volume
197
Category
Article
ISSN
0304-3940

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Recently, the neurotoxic amyloid โค-peptide was shown to up-regulate polyamine metabolism by increasing ornithine decarboxylase (ODC) activity and polyamine uptake by initiating free radical damage in Alzheimer's disease (AD). 1 Because of these findings, polyamines have been considered to play an im