Multidrug resistance (MDR) is associated with the expression of P-glycoprotein (P-gp), an ATP-dependent transporter which expels anti-cancer drugs from cells. In the present study, MDR1 P-gp was immunodetected by Western blot analysis in 60 human brain tumors, including meningiomas, schwannomas, low
Brain Microvascular P-Glycoprotein and a Revised Model of Multidrug Resistance in Brain
β Scribed by Pamela L. Golden; William M. Pardridge
- Book ID
- 110247690
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 193 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0272-4340
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
P-Glycoprotein (PGP), a product of the multidrug resistance gene (mdr), acts as an adenosine triphosphate-dependent drug efflux system in cells. Initially, PGP was found in cancer cells, but it is now known that PGP is richly distributed in the adult brain. Passage to the central nervous system is l
BACKGROUND. Despite extensive investigation, the role of MDR of human cancer remains unclear. Canine lymphoma is a spontaneously arising correlate of human non-Hodgkin's lymphoma that may complement other in vivo models for investigation of issues related to MDR. METHODS. Immunoreactivity of primary