Three patients with metastatic malignant melanoma, 2 of whom were males with primary lesion on the shoulder, and a female with primary lesion on the ankle, with Clark's level III-IV, completely responded to interferon-DTIC, but failed in the brain. Radiologically, all the lesions were peripheral in
β¦ LIBER β¦
Brain metastases of metastatic malignant melanoma: Response to DTIC and interferon-gamma
β Scribed by Dirk Schadendorf; Margitta Worm; Beate M. Czarnetzki
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 397 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0167-594X
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## Abstract Thiol redox status can affect important functions both intracellularly and extracellularly. The plasma membrane enzyme Ξ³βglutamyl transpeptidase (GGT), which plays a crucial role in cellular handling of thiols, is often expressed in malignant tumors, including melanoma, although its exp