Brain Ischemia: Basic Concepts and Clinical Relevance

✍ Scribed by Louis R. Caplan MD (auth.), Louis R. Caplan MD (eds.)

• Publisher: Springer-Verlag London
• Year: 1995
• Tongue: English
• Leaves: 367
• Edition: 1
• Category: Library

✦ Synopsis

Professor Caplan has extensively edited the book to shape and organize the contents into a succinct presentation by experts of the basic science and clinical aspects of the topic. The text has been divided into sections: The Brain.- Macroscopic and microscopic molecular aspects of brain ischemia, including pathophysiology, pathology, biochemistry, and clinical measurement.- Blood Vessels.- Their constitution and the pathology and physiology of the endothelium and arterial wall.- Blood Flow.- Its physics, control, rheology, and pathophysiology.- Blood.- The role of the cellular and serological constituents in coagulation and fibrinolysis. - Heart.- Sources of embolism and cardiac changes caused by brain ischemia.- And Epidemiology, Databases, and Trials. Prefatory remarks by Professor Caplan introduce each section. At the end of each section he relates the basic concepts to patient problems in the clinic, integrates the various contributions in the section, and covers other areas not discussed by the individual contributors.

✦ Table of Contents

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Prefatory Comments....Pages 3-6
Mechanisms of Cell Death in Ischemia....Pages 7-18
Positron Emission Tomography (PET) in Acute Ischemic Stroke: Pathophysiological and Clinical Implications....Pages 19-27
Excitotoxicity and Stroke....Pages 29-36
Growth Factors in Stroke....Pages 37-41
Ischemic Cerebral Edema....Pages 43-50
Concluding Comments....Pages 51-56
Front Matter....Pages 57-57
Prefatory Comments....Pages 59-60
Ocular Ischemia....Pages 61-73
Concluding Comments....Pages 75-79
Front Matter....Pages 81-81
Prefatory Comments....Pages 83-84
Coagulation....Pages 85-96
Immunohematologic Mechanisms in Stroke....Pages 97-103
Fibrinolysis and its Relevance to Acute Focal Cerebral Ischemia....Pages 105-119
Concluding Comments....Pages 121-126
Front Matter....Pages 127-127
Prefatory Comments....Pages 129-133
Atherosclerosis....Pages 135-150
Cerebral Vasoconstriction: Physiology, Pathophysiology and Occurrence in Selected Cerebrovascular Disorders....Pages 151-172
Endothelial Cells and Cerebrovascular Disease....Pages 173-183
Physical Factors in the Pathogenesis of Atheroma Formation....Pages 185-213
Front Matter....Pages 127-127
Microvascular Pathology....Pages 215-222
Concluding Comments....Pages 223-231
Front Matter....Pages 233-233
Prefatory Comments....Pages 235-236
Autoregulation, Hypertension and Regulation of the Cerebral Circulation....Pages 237-245
The Innervation of Pial Blood Vessels and their Role in Cerebrovascular Regulation....Pages 247-259
Rheology of Flow and its Effects....Pages 261-267
Pathophysiology of Raised Intracranial Pressure....Pages 269-272
Central Neurogenic Regulation of Regional Cerebral Blood Flow (rCBF) and Relationship to Neuroprotection....Pages 273-288
Concluding Comments....Pages 289-294
Front Matter....Pages 295-295
Prefatory Comments....Pages 297-298
Cardiac Disease and Embolic Sources....Pages 299-315
Heart and Brain Relationships....Pages 317-328
Concluding Comments....Pages 329-334
Front Matter....Pages 335-335
Prefatory Comments....Pages 337-341
Epidemiology and Trials....Pages 343-353
Stroke Data Banks and Stroke Registries....Pages 355-363
Concluding Comments....Pages 365-368
Back Matter....Pages 369-380

✦ Subjects

Neurology; Neurosciences; Neurosurgery; Anesthesiology; Neuroradiology