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Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomography

✍ Scribed by Dr. K. L. Leenders; R. S. J. Frackowiak; N. Quinn; C. D. Marsden

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
549 KB
Volume
1
Category
Article
ISSN
0885-3185

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✦ Synopsis

A 48-year-old man with typical Huntington's disease was investigated with computed tomography (CT) and positron emission tomography. Regional cerebral blood flow, oxygen extraction, oxygen and glucose utiIisation, L-Dopa uptake, and dopamine (D2) receptor binding were measured using several positronlabelled tracers. CT showed slight atrophy of the head of caudate but no cortical atrophy, although distinct frontal lobe dysfunction was present on psychometric testing. Oxygen and glucose metabolism and cerebral blood flow were decreased in the striata and to a lesser extent in frontal cortex. Cerebral blood flow was in the low normal range throughout the remainder of the brain. A normal metabolic ratio was found in all regions, since the changes in glucose utilisation paralleled those in oxygen consumption. The capacity of the striatum to store dopamine as assessed by L-[**F]-fluorodopa uptake was normal, but dopamine (D2) receptor binding was decreased when compared to normal subjects.

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