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Brain-derived neurotrophic factor-like immunoreactivity in the adult rat central nervous system predominantly distributed in neurons with substantial amounts of brain-derived neurotrophic factor messenger RNA or responsiveness to brain-derived neurotrophic factor

✍ Scribed by S Furukawa; Y Sugihara; F Iwasaki; H Fukumitsu; A Nitta; H Nomoto; Y Furukawa


Book ID
117492071
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
609 KB
Volume
82
Category
Article
ISSN
0306-4522

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Adult rat retinal ganglion cells (RGC) undergo degeneration after optic nerve transection. Studies have shown that exogenously applied neurotrophic factors such as brain-derived neurotrophic factor (BDNF) can attenuate axotomy-induced as well as developmental RGC death. Here, we examined whether gli