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Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington’s disease

✍ Scribed by Shotaro Kishikawa; Jian-Liang Li; Tammy Gillis; Michael M. Hakky; Simon Warby; Michael Hayden; Marcy E. MacDonald; Richard H. Myers; James F. Gusella

Book ID: 113812072
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 207 KB
Volume: 24
Category: Article
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2006.07.008

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## Abstract Huntington's disease (HD) is caused by the expansion of the number of CAG repeats on the chromosome 4p16.3, which results in elongated glutamine tract of huntingtin. The purpose of this work was to examine the interaction between the normal and mutant alleles of this gene and their effe